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KMID : 0362319960210010353
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Journal of Korean Academy of Operative Dentistry
1996 Volume.21 No. 1 p.353 ~ p.359
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A study on the concentrations of leukotriene B4 in relation to the clinical symptom of pulpitis in human dental pulp
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Abstract
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The purpose of this study was to investigate the concentrations of Leukotriene B4 in relation to the clinical symptom of pulpitis in human dental pulp.
Pulps obtained from 3 groups of teeth : normal uniflamed teeth(N=22), asymptomatic teeth with deep caries or large restorations(N=15). Pulps were dissected from normal uninflamed teeth and extirpated from asymptomatic and symptomatic teeth during
routine endedontic treatment and stored in liquid nitrogen(-70℃). The levels of Leukotriene B4 in individual or pooled pulps were measured by radioimmunoassay and the mean levels of each group were compared statistically(Kruskall-Wallis oneway
ANOVA
test).
@ES The results were as followings;
@EN 1. In noral pulp, low levels of Leukotriene B4 were measured.
2. In pulps from asymptomatic and symptomatic teeth had significantly higher levels of Leukotriene B4 than normal pulps(p<0.01).
3. The levels of Leukotriene B4 in pulps from symptomatic teeth were lignificantly higher than those of pulps from asymptomatic teeth(p<0.01).
These results suggest that Leukotriene B4 play a cretain role in inflammatory process of dental pulp and have a relationship with clinical symptoms of pulpitis.
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